The FDI-Colgate Caries Prevention Partnership (CPP) was formed in 2015. This new aspiring partnership aims at enhancing caries prevention through information, education and other activities targeting dental health professionals, patients and the public in general. It has the ambition to help shift the focus of dental practitioners from a Restorative approach to dental caries management to delivering Preventive Dental Medicine. The present White Paper aims to provide the foundation knowledge that is necessary to understand why change is important, and how it can be initiated and conducted.