Should Pediatricians Refuse to Treat Patients Who Don’t Vaccinate?

Parents who don’t want to vaccinate their children are a perennial sore subject in my profession. The question bubbled up again this spring at the American Academy of Pediatrics’ Annual Leadership Forum, where academy leaders vote on issues of concern to pediatricians across the country…

Spotlight

aspect imaging

Aspect Imaging, Ltd. is the world’s leader in the design and development of compact MR imaging systems for preclinical and medical applications. With breakthrough technology in high-performance, permanent magnets, we offer unparalleled solutions designed to provide the information only available with MRI without the complexity, infrastructure constraints and extraordinary maintenance costs often associated with traditional MRI systems.

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Health Technology, Digital Healthcare

6 Tips On Discussing Your Mental Health Issues With Your Friends

Article | July 14, 2023

Do you have a difficult time explaining your mental health issues to your family and friends? If so, here are six suggestions on how to discuss your mental health issues with your friends and relatives. 1. Talk to a counselor: The most important thing that you need to do is to talk to a counselor about your mental health problems. Seeking professional help will go a long way in overcoming your current issues. In addition, a counselor will be able to give you additional advice on how to deal with your friends and family members. 2. Don’t argue with others: It is important that you do not get into arguments with those who are giving you a hard time. Your number one priority is getting your life back on track. Your health is more important than what other people may think. 3. Watch who you hang out with: It is important to surround yourself with positive people. Try to keep your distance from those people who are giving you a difficult time. Remember that your goal is to remain positive and hopeful. Do not let the negative people in your life bring you down. 4. You are not alone: It can be very frustrating to deal with your mental health issues when your friends and relatives are on your case. Remember, you are not alone. There are millions of people around the world who struggle with their fears, anxieties, and depression. The key is to find those people who can relate to you. 5. Stand your ground: It is important to stand your ground when dealing with family members and friends who are giving you a hard time. Explain your situation and your feelings to the people in your life, however don’t let them hassle you. Your number one priority is to get better and not to please everyone that you know. 6. Join a support group: There are many mental health support groups in your area that can help you. Many hospitals, churches, and counselors in your area will be able to provide you with a list of groups. These mental health organizations will be supportive of your situation and they can give you additional advice regarding your problems.

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Digital Healthcare

Transforming Patient Records: Impact of Top 10 EHR Tools

Article | November 29, 2023

Delve into the EHR tools reshaping the healthcare industry for an efficient and patient-centric future. Unlock streamlined workflows and data-driven decision-making through these EHR software tools. Adopting an EHR tool has become crucial for clinics and healthcare providers striving to revolutionize their operations and deliver a high standard of care. These innovative EHR software tools possess the potential to transform healthcare workflows, enabling clinics to optimize processes, streamline operations, and provide an exceptional level of care to patients. From facilitating seamless communication and improving operational efficiency to enhancing patient satisfaction, EHR tools unlock possibilities for improved operations, accurate claims processing, and enhanced financial management within practices. This article explores the top 10 electronic health record tools that are reshaping the healthcare industry and paving the way for a more efficient and patient-centric future. 1. Avalon EHR It is an EHR evaluation tool that prioritizes robust physician-patient engagement, setting it apart from complex electronic health record (EHR) systems. With an unwavering focus on reliability and security, Avalon offers a cutting-edge solution for the future of healthcare. Its key features include CureMD's clinical overview, which presents alarms, trends, and patient histories on a single screen, ensuring comprehensive insights. The platform also boasts a specialized rheumatology section with templates for typical symptoms, simplifying documentation processes. Furthermore, Avalon provides regular updates for various medical specialties following CPT and ICD codes, ensuring compliance, proper medical procedures, and diagnosis recording. Notably, it supports automated overnight transcription of dictations into templates, significantly reducing the time and billing service partners' costs associated with finding and documenting clinical findings. 2. AdvancedBiller The AdvancedBiller Grow program offers medical billing companies a comprehensive and advantageous solution, combining industry-leading software solutions with exclusive partner benefits. This program is designed to drive optimal outcomes by providing a unified practice management workflow, excellent support, free promotional opportunities, and competitive, scalable pricing. With a focus on boosting performance and profitability, AdvancedBiller equips businesses with the necessary tools to excel in their field. The program features custom health plans that assist doctors in managing individual patient needs based on age, sex, and lab findings. Additionally, it offers customizable note-taking templates to align with specific workflows and preferences. This EHR tool also facilitates telemedicine appointments, enabling patients to communicate face-to-face with their doctors and receive important notifications. Furthermore, the program enhances data management by allowing doctors to save sensitive information and screenshots during conference calls securely. By leveraging the AdvancedBiller Grow program, medical billing companies can optimize operations, deliver superior care, and achieve notable success. 3. Halemind EHR integration tools, such as Halemind, present a game-changing solution that enables clinics to elevate their operations and provide superior patient care. This comprehensive platform offers many features, including appointment scheduling, patient registrations, check-ins, consultations, prescriptions, billing, and reporting, all aimed at delivering a seamless customer experience. With Halemind, clinics can transform their business and scale up their operations. The platform also provides specialized functionalities for pharmacies, allowing real-time access to customer histories, order tracking, invoicing, and supplier management. In addition, hospitals can benefit from Halemind's capabilities, such as operations planning, invoicing, payment collection, patient sample tracking, and customizable data display. Medical facilities can further enhance their efficiency by utilizing its in-patient module for managing wards, rooms, and beds and generating discharge reports. 4. SIMPLEX HIMES Patient Portal SIMPLEX HIMES software incorporates an optional yet powerful feature, the Patient Portal and Mobile Application, designed to revolutionize patient engagement and communication. This EHR tool seamlessly integrates with existing websites, providing healthcare facilities with a comprehensive EHR tool to enhance the patient experience. The Patient Portal enables efficient control of patient intake, bed availability monitoring, operating room scheduling, and centralized patient demographic management within hospitals. The software streamlines operations for pathology labs by managing information about referral laboratories, generating barcodes for sample tracing, and delivering timely test result alerts via email or text. Additionally, patients benefit from self-service portals, empowering them to conveniently schedule appointments, access medical records, locate service provider locations, and communicate with their doctors. 5. Patient Engagement The Patient Engagement tool offers patients unparalleled access to their personal health information, visit summaries, and lab results, empowering them to take an active role in their healthcare journey. With the help of this EHR tool, patients can conveniently book appointments online using the healow Open Access feature, efficiently manage their medications, and engage in secure messaging with their healthcare providers. In addition, the eCW software utilized within the tool provides organized data capture, trend analysis, and customizable documentation options for various healthcare specialties. Clinicians can effortlessly retrieve any aspect of the patient record through the Patient Hub, ensuring complete and efficient access to vital information. Furthermore, eClinicalWorks Version 11 introduces Eva, a computer program that assists physicians in evaluating patient records, leveraging details from the Progress Note tool and data flowsheets. This advanced functionality enhances clinical decision-making and promotes efficient patient care. 6. Electronic Prescription The Electronic Prescription tool revolutionizes prescription management in the healthcare industry, offering a seamless and efficient solution for healthcare providers. This advanced software streamlines the prescription process by eliminating traditional prescription pads, enhancing convenience and accuracy. AllegianceMD, integrated within the tool, enables patients to fill out their history and demographic information online within defined clinic limits, facilitating seamless integration of patient information. This EHR tool encompasses a range of features, including an active/inactive medicine list, e-refill requests, an allergy list, and comprehensive drug interaction checks. The software also includes a lab module for efficiently tracking test results and follow-ups. With its extended functionalities, the Electronic Prescription tool elevates prescription management, promoting patient safety and enhancing workflow efficiency for healthcare providers. 7. Telehealth WRS Health Telehealth offers healthcare providers and patients a secure and reliable virtual care experience. With seamless integration into the electronic health record (EHR), this comprehensive telehealth platform provides a single platform for managing virtual patient encounters. Designed with ease of use in mind, both patients and providers can navigate the user-friendly interface effortlessly. This EHR comparison tool is a safe alternative to in-office visits, offering private and secure online consultations that comply with HIPAA regulations. This telehealth solution ensures a smooth and efficient workflow with its seamless integration of clinical and revenue cycle management (RCM) functionalities. 8. Practice Management for Billing Companies The Practice Management tool offered by SequelMed is a comprehensive solution that streamlines operations and enhances efficiency in healthcare practices. This advanced tool automates various tasks, including billing, claim processing, revenue management & clinical procedures, and generates analytical reports for comprehensive insights, with the option of bundled or separate programs for electronic health records and practice management. The software provides interoperability with imaging systems and medical equipment through HL7 and DICOM interfaces, offering flexibility in deployment options with on-site or cloud hosting. In addition to its core functionalities, it enhances patient engagement with real-time communication, online patient registration, active prescription lists, immunization schedules, and a patient portal. The Practice Management Tool simplifies computerized prescription processes and promotes connectivity across healthcare systems, enabling healthcare providers to optimize their operations and deliver efficient, patient-centered care. 9. Medical Practice Management Software The Practice Management Software offers healthcare providers a powerful solution to streamline operations, ensure accurate claims processing, and expedite reimbursement cycles. With its intuitive design and comprehensive features, this software empowers practices to take control of their operations and optimize efficiency. Users can benefit from the HIPAA-compliant claims clearinghouse provided by NueMD, allowing for the seamless processing of unlimited claims. The software makes it easier to submit paper claims by reducing it to a single click, and it also simplifies payment transactions by incorporating credit card processing. Additionally, the ONC-ATCB-certified EHR enhances clinical workflow by providing charting capabilities, e-prescribing, laboratory report monitoring, and secure fax management. 10. LiquidEHR LiquidEHR is a cloud-based electronic health record (EHR) solution ideal for small and midsize optometry practices. It offers a range of features to manage medical records, scheduling, and billing effectively. The software includes specialized tools specific to optometry, such as historical IOP charts, drawing tools, built-in eye charts, frames data integration, and image management. Clinicians using LiquidEHR have access to electronic insurance filing tools, patient recalls, drug interactions and allergy checks, problem lists, medication recommendations, educational resources, vital signs monitoring, and more. The system also ensures data security through access controls, audit logs, and encryption features. Future Scope By staying informed about the top EHR tools highlighted in this article, medical practitioners can unlock streamlined workflows, improved communication, and data-driven decision-making to optimize clinical practices and deliver exceptional patient care. The future of EHR assessment tools looks promising, with emerging trends like artificial intelligence, machine learning, interoperability, and telehealth shaping the way forward. By embracing these advancements, healthcare professionals can stay ahead of the curve, maximize operational efficiency, and position themselves for success in the healthcare industry.

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Health Technology, Digital Healthcare

Enhancing Network Resilience in the Healthcare Sector to Prevent Downtime and Unusable Uptime

Article | August 16, 2023

Your patients have grown to trust your expertise and recommendations in matters regarding their healthcare. As the sector transitions into a more digital playing field, uninterrupted network connectivity is more than just a bonus; it’s a necessity. While there are many different challenges to completely integrating your practice into the digital world, internet outages are the costliest. Downtime can be caused by various factors, which can compromise patient safety, the faith your team instills in you, and your practice’s reputation and revenue. However, investing in the means to maintain a resilient network lets you maximize your network uptime to optimize resources. We'll look at four different strategies and their benefits for your infrastructure so you can focus on what you do best: providing healthcare excellence to your patients. Strengthening Network Infrastructure The traditional way of doing things may be great for your remedies and techniques. Still, with a growing number of patients and their contextually relevant demands, your network needs to be able to accommodate many different booking requests, increase user activity on your server, and store sensitive patient information. High-speed internet connections enhance your network performance and let you, your team, and your patients make the most of your uninterrupted uptime. Fiber-optic networks, when combined with load balancing and proper segmentation, can diffuse and direct network traffic efficiency and prevent congestion, which prevents downtime due to overload. Implementing Network Monitoring and Management Tools Much like your patients visit your practice to ensure everything is all right with the current state of their health, your network must also receive the same treatment. Identifying and pre-emptively resolving potential issues and vulnerabilities will prevent much more destructive or expensive problems from occurring. Use real-time tools to monitor your bandwidth usage and gain visibility of potential bottlenecks. Tools that offer risk monitoring deliver alerts about critical events that pose a threat to your business continuity. Your IT team will be better equipped to troubleshoot issues promptly and optimize performance. Conducting Regular Network Assessments and Audits Once you have the proper monitoring tools to manage your network topology better, proactive troubleshooting is a great way to spot-check whether your current solution is working as it should. A network audit is much like proactive troubleshooting; you are looking to see if anything could harm the overall system and catch it before it can develop. When auditing a network, the primary focus should be security measures. If patient and confidential data is not secure, the smooth operations of your business are the least of your worries. When conducting an audit, consulting with a network service provider will help identify issues with your protocols, data encryption, and firewall configuration. Establishing Redundancy and Disaster Recovery Plans Backing up private and confidential data is crucial to ensuring that sensitive information is not lost or exposed. Minimizing network downtime can often be achieved by having backup systems that will keep running in the event of an attack or outage. For example, a dedicated Cloud Access Network, power supplies, and switches will go a long way. When creating an internet contingency plan, outline steps and protocols with your team that you will take in the event of a complete failure, including things such as brand reputation management, customer service, and data loss prevention. Looking Forward As the lines between in-person and digital are blurred, navigating the complexities of implementing a robust network is paramount to your business. Strengthening your infrastructure, integrating redundant systems, and conducting regular audits and assessments with the proper monitoring and management tools will help you maximize uptime usage and minimize network downtime. Although overwhelming, working with a reputable network service provider can help you embrace your network topology to remain competitive.

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Addressing social determinants of health with data interoperability

Article | April 20, 2020

Across the spectrum of healthcare delivery – payor, provider, vendor, consumer, there is a land rush underway to embrace consumer-centric care. With tools like value-based care, chronic disease management, retail services, analytics, and remote patient monitoring, healthcare organizations are pivoting towards capabilities that provide a deeper understanding of patient behaviors and address the whole patient and not just the condition.

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Spotlight

aspect imaging

Aspect Imaging, Ltd. is the world’s leader in the design and development of compact MR imaging systems for preclinical and medical applications. With breakthrough technology in high-performance, permanent magnets, we offer unparalleled solutions designed to provide the information only available with MRI without the complexity, infrastructure constraints and extraordinary maintenance costs often associated with traditional MRI systems.

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Health Technology

Texas Children's Hospital And Baylor College of Medicine COVID-19 Vaccine Technology Secures Emergency Use Authorization In India

Texas Children Hospital | December 29, 2021

Texas Children's Hospital and Baylor College of Medicine announced today that CORBEVAX™, a protein sub-unit COVID-19 Vaccine, whose technology was created and engineered at its Center for Vaccine Development (CVD), has received Emergency Use Authorization (EUA) approval from the Drugs Controller General ofIndia(DCGI)to launch inIndiawith other underserved countries to follow. Dubbed "The World's COVID-19 Vaccine", it uses a traditional recombinant protein-based technology that will enable its production at large scales making it widely accessible to inoculate the global population. The initial construct and production process of the vaccine antigen was developed at Texas Children's Hospital CVD, led by co-directors Drs. Maria Elena Bottazzi and Peter Hotez and in-licensed from BCM Ventures, Baylor College of Medicine's integrated commercialization team, to Hyderabad-based vaccine and pharmaceutical company Biological E. Limited (BE). CORBEVAX™ after completing two Phase III clinical trials involving more than 3000 subjects was found to be safe, well tolerated and immunogenic: CORBEVAX™ demonstrated superior immune response in comparison with COVISHIELD™ vaccine when assessed for Neutralizing Antibody (nAb) Geometric Mean Titers (GMT) against the Ancestral-Wuhan strain and the globally dominant Delta variant. CORBEVAX™ vaccination also generated significant Th1 skewed cellular immune response. CORBEVAX™ nAb GMT against Ancestral-Wuhan strain is indicative of vaccine effectiveness of >90% for prevention of symptomatic infections based on the Correlates of Protection assessment performed during Moderna and Astra-Zeneca vaccine Phase III studies. CORBEVAX™ nAb GMT against the Delta strain indicates a vaccine effectiveness of >80 percent for the prevention of symptomatic infections based on published studies. While none of the subjects who took CORBEVAX™ or COVISHIELD™ had serious adverse events, CORBEVAX™ had 50 percent fewer adverse events than COVISHIELD™. In the continuous monitoring of phase II studies, CORBEVAX™ showed high persistence of immune response as indicated by <30% drop in nAb GMT till 6 months second dose as compared to >80% drop observed with majority of the vaccines. "Protein-based vaccines have been widely used to prevent many other diseases, have proven safety records, and use economies of scale to achieve low-cost scalability across the world," said Dr. Maria Elena Bottazzi, Professor and Associate Dean of the National School of Tropical Medicine at Baylor and Co-Director of the Texas Children's Hospital Center for Vaccine Development. "Our decade-long studies advancing coronavirus vaccine prototypes has led to the creation of this vaccine, which will fill the access gap created by the more expensive, newer vaccine technologies and that today are still not able to be quickly scaled for global production." The need for safe, streamlined, low-cost vaccines for middle- to low-income countries is central to the world's fight against the COVID-19 pandemic. Without widespread vaccination of populations in the Global South, additional virus variants will arise, hindering the progress achieved by currently available vaccines in the United States and other Western countries. "This announcement is an important first step in vaccinating the world and halting the pandemic. Our vaccine technology offers a path to address an unfolding humanitarian crisis, namely the vulnerability the low- and middle-income countries face against the delta variant," said Dr. Peter Hotez, Professor and Dean of the National School of Tropical Medicine at Baylor and Co-Director of the Texas Children's Hospital Center for Vaccine Development. "Widespread and global vaccination with our Texas Children's-Baylor-BE vaccine would also forestall the emergence of new variants. We have previously missed that opportunity for the alpha and delta variant. Now is our chance to prevent a new global wave from what might follow." "Over the years, we have worked to make quality vaccines and pharmaceutical products accessible to families around the world. With this as our backdrop, we resolved to develop an affordable and effective COVID-19 vaccine. It has now become a reality. We deeply appreciate Texas Children's Hospital Center for Vaccine Development, Baylor, CEPI, the Bill and Melinda Gates Foundation, and the government of India for their continuous support and cooperation during this journey. The combined efforts & unceasing support demonstrate that we can collectively overcome any challenge". Mahima Datla, Managing Director, Biological E. Limited ABOUT TEXAS CHILDREN'S HOSPITAL Texas Children's Hospital, a not-for-profit health care organization, is committed to creating a healthier future for children and women throughout the global community by leading in patient care, education and research. Consistently ranked as the best children's hospital in Texas, and among the top in the nation, Texas Children's has garnered widespread recognition for its expertise and breakthroughs in pediatric and women's health. The hospital includes the Jan and Dan Duncan Neurological Research Institute; the Feigin Tower for pediatric research; Texas Children's Pavilion for Women, a comprehensive obstetrics/gynecology facility focusing on high-risk births; Texas Children's Hospital West Campus, a community hospital in suburban West Houston; and Texas Children's Hospital The Woodlands, the first hospital devoted to children's care for communities north of Houston. The organization also created Texas Children's HealthPlan, the nation's first HMO for children; has the largest pediatric primary care network in the country, Texas Children's Pediatrics; Texas Children's Urgent Care clinics that specialize in after-hours care tailored specifically for children; and a global health program that's channeling care to children and women all over the world. Texas Children's Global Health program leads efforts that advance health care equity through innovative collaboration in care, education and research for underserved populations globally. Texas Children's Hospital is affiliated with Baylor College of Medicine. ABOUT TEXAS CHILDREN'S HOSPITAL CENTER FOR VACCINE DEVELOPMENT Texas Children's Hospital Center for Vaccine Development is one of the leading vaccine development centers in the world. Established in Washington DC as the Sabin Vaccine Institute Product Development Partnership (PDP) in the year 2000 and after relocating to the Texas Medical Center in 2011, it rebranded as Texas Children's Center for Vaccine Development. For the past two decades it has acquired an international reputation as a non-profit PDP, advancing vaccines for poverty-related neglected tropical diseases (NTDs) and emerging infectious diseases of pandemic importance. In addition, it builds and strengthens capacity for vaccine development locally and with foreign nations and leads global efforts to guide and influence vaccine policy and advocacy through "vaccine diplomacy" as an international bridge for peace and vaccine development capacity. ABOUT BCM VENTURES Baylor College of Medicine Ventures is the commercial engine of the health sciences university, created to support the translation of academic knowledge and intellectual assets for the benefit of society. We do this by engaging university innovators, entrepreneurs and industry to fully develop ideas along their best commercial path. We foster a culture of commercialization and engage with industry to identify market opportunities for collaborative ventures. ABOUT BIOLOGICAL E. LIMITED Biological E. Limited (BE), a Hyderabad-based Pharmaceuticals & Biologics Company founded in 1953, is the first private sector biological products company in India and the first pharmaceutical company in Southern India. BE develops, manufactures and supplies vaccines and therapeutics. BE supplies its vaccines to over 100 countries and its therapeutic products are sold in India and the USA. BE currently has 8 WHO-prequalified vaccines in its portfolio. In recent years, BE has embarked on new initiatives for organisational expansion such as developing generic injectable products for the regulated markets, exploring synthetic biology and metabolic engineering as a means to manufacture APIs sustainably and developing novel vaccines for the global market.

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Health Technology

Nemours Children's Health Chooses the Innovaccer Health Cloud to Support Value-Based Whole-Person Care

Innovaccer Inc. | October 13, 2021

Today Innovaccer Inc., the Health Cloud company, announced a partnership with Nemours Children's Health, one of the nation's largest clinically integrated pediatric health systems, to create a unified data platform designed to accelerate Nemours' mission to transform children's health through a holistic care model. The partnership will integrate and activate clinical and claims data from across the health system to enable intelligent point-of-care analytics that can help identify and close care gaps, optimize management of at-risk lives, and improve clinical outcomes for pediatric patients. Nemours' clinically integrated network (CIN), Delaware Children's Health Network, will leverage the InnovaccerⓇ Health Cloud for clinical and financial insights for 50K+ patients in their network. The Health Cloud's advanced analytics can then use this unified patient data to generate clinical and business insights that support effective cost, utilization, and risk management across the CIN, and across multiple provider and payer contracts. Customizable dashboards will allow the CIN leadership to drill into and understand cost, utilization, risk trends; and digitally transform population risk stratification and health management techniques to identify and address specific population management challenges, match risk with levels of care, individualize treatment plans to lower risk and improve function, and ensure alignment with value-based care models. Indeed, as Nemours Children's Health enters its value-based full-risk contracts they will be using the Innovaccer Health Cloud's intrinsic interoperability and data activation capabilities to integrate payer feeds from both Medicaid and Commercial payers in both the Delaware Valley and Florida—ensuring a 360° actionable view of clinical and financial information. "Our goal is simple—to redefine children's health by helping our communities and families ensure the healthiest futures for our children. By bringing the full richness of our children's healthcare data together, we can better see and understand 'the big picture,' and address all of the factors that influence a child's health. This partnership will help us continue to deliver the safe, high-quality, whole-person care every child deserves." Jonathan Miller, Medical Director for the Nemours Value Based Services Organization About Nemours Children's Health Nemours Children's Health is one of the nation's largest multistate pediatric health systems, including two free-standing children's hospitals and a network of nearly 80 primary and specialty care practices across five states. Nemours mission is "to provide leadership, institutions, and services to restore and improve the health of children through care and programs not readily available, with one high standard of quality and distinction, regardless of the recipient's financial status." Nemours seeks to transform the health of children by adopting a holistic health model that utilizes innovative, safe, and high-quality care, while also caring for the health of the whole child beyond medicine. Nemours also powers the world's most-visited website for information on the health of children and teens, KidsHealth.org. The Nemours Foundation, established through the legacy and philanthropy of Alfred I. duPont, provides pediatric clinical care, research, education, advocacy and prevention programs to the children, families and communities it serves. About Innovaccer Innovaccer Inc., the Health Cloud company, is a leading San Francisco-based healthcare technology company committed to helping healthcare care as one. The Innovaccer Health Cloud unifies patient data across systems and settings, and empowers healthcare organizations to rapidly develop scalable, modern applications that improve clinical, operational, and financial outcomes. Innovaccer's solutions have been deployed across more than 1,000 care settings in the U.S., enabling more than 37,000 providers to transform care delivery and work collaboratively with payers and life sciences companies. Innovaccer has helped organizations integrate medical records for more than 24 million people and generate more than $600 million in savings. Innovaccer is recognized as a Best in KLAS vendor for 2021 in population health management and is the #1 customer-rated vendor by Black Book.

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First rapid detection Zika test now available through collaboration with Texas Children’s Hospital and Houston Methodist Hospital

Texas Children's Hospital | February 23, 2016

Collaboration between two Texas Medical Center institutions has resulted in today’s release of the country’s first hospital-based rapid tests for the Zika virus.Pathologists and clinical laboratory scientists at Texas Children’s Hospital and Houston Methodist Hospital developed the Zika direct test in a matter of weeks as part of the L.E. and Virginia Simmons Collaborative in Virus Detection and Surveillance.

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Health Technology

Texas Children's Hospital And Baylor College of Medicine COVID-19 Vaccine Technology Secures Emergency Use Authorization In India

Texas Children Hospital | December 29, 2021

Texas Children's Hospital and Baylor College of Medicine announced today that CORBEVAX™, a protein sub-unit COVID-19 Vaccine, whose technology was created and engineered at its Center for Vaccine Development (CVD), has received Emergency Use Authorization (EUA) approval from the Drugs Controller General ofIndia(DCGI)to launch inIndiawith other underserved countries to follow. Dubbed "The World's COVID-19 Vaccine", it uses a traditional recombinant protein-based technology that will enable its production at large scales making it widely accessible to inoculate the global population. The initial construct and production process of the vaccine antigen was developed at Texas Children's Hospital CVD, led by co-directors Drs. Maria Elena Bottazzi and Peter Hotez and in-licensed from BCM Ventures, Baylor College of Medicine's integrated commercialization team, to Hyderabad-based vaccine and pharmaceutical company Biological E. Limited (BE). CORBEVAX™ after completing two Phase III clinical trials involving more than 3000 subjects was found to be safe, well tolerated and immunogenic: CORBEVAX™ demonstrated superior immune response in comparison with COVISHIELD™ vaccine when assessed for Neutralizing Antibody (nAb) Geometric Mean Titers (GMT) against the Ancestral-Wuhan strain and the globally dominant Delta variant. CORBEVAX™ vaccination also generated significant Th1 skewed cellular immune response. CORBEVAX™ nAb GMT against Ancestral-Wuhan strain is indicative of vaccine effectiveness of >90% for prevention of symptomatic infections based on the Correlates of Protection assessment performed during Moderna and Astra-Zeneca vaccine Phase III studies. CORBEVAX™ nAb GMT against the Delta strain indicates a vaccine effectiveness of >80 percent for the prevention of symptomatic infections based on published studies. While none of the subjects who took CORBEVAX™ or COVISHIELD™ had serious adverse events, CORBEVAX™ had 50 percent fewer adverse events than COVISHIELD™. In the continuous monitoring of phase II studies, CORBEVAX™ showed high persistence of immune response as indicated by <30% drop in nAb GMT till 6 months second dose as compared to >80% drop observed with majority of the vaccines. "Protein-based vaccines have been widely used to prevent many other diseases, have proven safety records, and use economies of scale to achieve low-cost scalability across the world," said Dr. Maria Elena Bottazzi, Professor and Associate Dean of the National School of Tropical Medicine at Baylor and Co-Director of the Texas Children's Hospital Center for Vaccine Development. "Our decade-long studies advancing coronavirus vaccine prototypes has led to the creation of this vaccine, which will fill the access gap created by the more expensive, newer vaccine technologies and that today are still not able to be quickly scaled for global production." The need for safe, streamlined, low-cost vaccines for middle- to low-income countries is central to the world's fight against the COVID-19 pandemic. Without widespread vaccination of populations in the Global South, additional virus variants will arise, hindering the progress achieved by currently available vaccines in the United States and other Western countries. "This announcement is an important first step in vaccinating the world and halting the pandemic. Our vaccine technology offers a path to address an unfolding humanitarian crisis, namely the vulnerability the low- and middle-income countries face against the delta variant," said Dr. Peter Hotez, Professor and Dean of the National School of Tropical Medicine at Baylor and Co-Director of the Texas Children's Hospital Center for Vaccine Development. "Widespread and global vaccination with our Texas Children's-Baylor-BE vaccine would also forestall the emergence of new variants. We have previously missed that opportunity for the alpha and delta variant. Now is our chance to prevent a new global wave from what might follow." "Over the years, we have worked to make quality vaccines and pharmaceutical products accessible to families around the world. With this as our backdrop, we resolved to develop an affordable and effective COVID-19 vaccine. It has now become a reality. We deeply appreciate Texas Children's Hospital Center for Vaccine Development, Baylor, CEPI, the Bill and Melinda Gates Foundation, and the government of India for their continuous support and cooperation during this journey. The combined efforts & unceasing support demonstrate that we can collectively overcome any challenge". Mahima Datla, Managing Director, Biological E. Limited ABOUT TEXAS CHILDREN'S HOSPITAL Texas Children's Hospital, a not-for-profit health care organization, is committed to creating a healthier future for children and women throughout the global community by leading in patient care, education and research. Consistently ranked as the best children's hospital in Texas, and among the top in the nation, Texas Children's has garnered widespread recognition for its expertise and breakthroughs in pediatric and women's health. The hospital includes the Jan and Dan Duncan Neurological Research Institute; the Feigin Tower for pediatric research; Texas Children's Pavilion for Women, a comprehensive obstetrics/gynecology facility focusing on high-risk births; Texas Children's Hospital West Campus, a community hospital in suburban West Houston; and Texas Children's Hospital The Woodlands, the first hospital devoted to children's care for communities north of Houston. The organization also created Texas Children's HealthPlan, the nation's first HMO for children; has the largest pediatric primary care network in the country, Texas Children's Pediatrics; Texas Children's Urgent Care clinics that specialize in after-hours care tailored specifically for children; and a global health program that's channeling care to children and women all over the world. Texas Children's Global Health program leads efforts that advance health care equity through innovative collaboration in care, education and research for underserved populations globally. Texas Children's Hospital is affiliated with Baylor College of Medicine. ABOUT TEXAS CHILDREN'S HOSPITAL CENTER FOR VACCINE DEVELOPMENT Texas Children's Hospital Center for Vaccine Development is one of the leading vaccine development centers in the world. Established in Washington DC as the Sabin Vaccine Institute Product Development Partnership (PDP) in the year 2000 and after relocating to the Texas Medical Center in 2011, it rebranded as Texas Children's Center for Vaccine Development. For the past two decades it has acquired an international reputation as a non-profit PDP, advancing vaccines for poverty-related neglected tropical diseases (NTDs) and emerging infectious diseases of pandemic importance. In addition, it builds and strengthens capacity for vaccine development locally and with foreign nations and leads global efforts to guide and influence vaccine policy and advocacy through "vaccine diplomacy" as an international bridge for peace and vaccine development capacity. ABOUT BCM VENTURES Baylor College of Medicine Ventures is the commercial engine of the health sciences university, created to support the translation of academic knowledge and intellectual assets for the benefit of society. We do this by engaging university innovators, entrepreneurs and industry to fully develop ideas along their best commercial path. We foster a culture of commercialization and engage with industry to identify market opportunities for collaborative ventures. ABOUT BIOLOGICAL E. LIMITED Biological E. Limited (BE), a Hyderabad-based Pharmaceuticals & Biologics Company founded in 1953, is the first private sector biological products company in India and the first pharmaceutical company in Southern India. BE develops, manufactures and supplies vaccines and therapeutics. BE supplies its vaccines to over 100 countries and its therapeutic products are sold in India and the USA. BE currently has 8 WHO-prequalified vaccines in its portfolio. In recent years, BE has embarked on new initiatives for organisational expansion such as developing generic injectable products for the regulated markets, exploring synthetic biology and metabolic engineering as a means to manufacture APIs sustainably and developing novel vaccines for the global market.

Read More

Health Technology

Nemours Children's Health Chooses the Innovaccer Health Cloud to Support Value-Based Whole-Person Care

Innovaccer Inc. | October 13, 2021

Today Innovaccer Inc., the Health Cloud company, announced a partnership with Nemours Children's Health, one of the nation's largest clinically integrated pediatric health systems, to create a unified data platform designed to accelerate Nemours' mission to transform children's health through a holistic care model. The partnership will integrate and activate clinical and claims data from across the health system to enable intelligent point-of-care analytics that can help identify and close care gaps, optimize management of at-risk lives, and improve clinical outcomes for pediatric patients. Nemours' clinically integrated network (CIN), Delaware Children's Health Network, will leverage the InnovaccerⓇ Health Cloud for clinical and financial insights for 50K+ patients in their network. The Health Cloud's advanced analytics can then use this unified patient data to generate clinical and business insights that support effective cost, utilization, and risk management across the CIN, and across multiple provider and payer contracts. Customizable dashboards will allow the CIN leadership to drill into and understand cost, utilization, risk trends; and digitally transform population risk stratification and health management techniques to identify and address specific population management challenges, match risk with levels of care, individualize treatment plans to lower risk and improve function, and ensure alignment with value-based care models. Indeed, as Nemours Children's Health enters its value-based full-risk contracts they will be using the Innovaccer Health Cloud's intrinsic interoperability and data activation capabilities to integrate payer feeds from both Medicaid and Commercial payers in both the Delaware Valley and Florida—ensuring a 360° actionable view of clinical and financial information. "Our goal is simple—to redefine children's health by helping our communities and families ensure the healthiest futures for our children. By bringing the full richness of our children's healthcare data together, we can better see and understand 'the big picture,' and address all of the factors that influence a child's health. This partnership will help us continue to deliver the safe, high-quality, whole-person care every child deserves." Jonathan Miller, Medical Director for the Nemours Value Based Services Organization About Nemours Children's Health Nemours Children's Health is one of the nation's largest multistate pediatric health systems, including two free-standing children's hospitals and a network of nearly 80 primary and specialty care practices across five states. Nemours mission is "to provide leadership, institutions, and services to restore and improve the health of children through care and programs not readily available, with one high standard of quality and distinction, regardless of the recipient's financial status." Nemours seeks to transform the health of children by adopting a holistic health model that utilizes innovative, safe, and high-quality care, while also caring for the health of the whole child beyond medicine. Nemours also powers the world's most-visited website for information on the health of children and teens, KidsHealth.org. The Nemours Foundation, established through the legacy and philanthropy of Alfred I. duPont, provides pediatric clinical care, research, education, advocacy and prevention programs to the children, families and communities it serves. About Innovaccer Innovaccer Inc., the Health Cloud company, is a leading San Francisco-based healthcare technology company committed to helping healthcare care as one. The Innovaccer Health Cloud unifies patient data across systems and settings, and empowers healthcare organizations to rapidly develop scalable, modern applications that improve clinical, operational, and financial outcomes. Innovaccer's solutions have been deployed across more than 1,000 care settings in the U.S., enabling more than 37,000 providers to transform care delivery and work collaboratively with payers and life sciences companies. Innovaccer has helped organizations integrate medical records for more than 24 million people and generate more than $600 million in savings. Innovaccer is recognized as a Best in KLAS vendor for 2021 in population health management and is the #1 customer-rated vendor by Black Book.

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First rapid detection Zika test now available through collaboration with Texas Children’s Hospital and Houston Methodist Hospital

Texas Children's Hospital | February 23, 2016

Collaboration between two Texas Medical Center institutions has resulted in today’s release of the country’s first hospital-based rapid tests for the Zika virus.Pathologists and clinical laboratory scientists at Texas Children’s Hospital and Houston Methodist Hospital developed the Zika direct test in a matter of weeks as part of the L.E. and Virginia Simmons Collaborative in Virus Detection and Surveillance.

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